Five Sooners scored in double figures, led by Kur Kuath's 14 points, and Oklahoma routed Florida A&M 85-54 on Saturday in Norman.
Austin Reaves added 12 points, while Brady Manek, Alondes Williams and DeVion Harmon each scored 10 points for the Sooners (3-1).
Johnny Brown scored 16 points to lead the Rattlers (0-4).