Lopez faced 15 batters, striking out six and walking one and was credited with her 11th win of the season with just one loss. She also tossed a complete-game no-hitter against Florida Atlantic earlier this season, striking out 13 in that decision. Last season, she combined with Paige Lowary on a no-hitter against Baylor.
The Sooner no-hitter was the 54th in program history.
Three Sooners collected two hits each. Freshman first baseman Grace Green went two-for-three, driving in two runs and scoring one, and senior right fielder Raegan Rogers had two hits, including a solo home run, and scored two runs.