Junior right-hander Nathan Wiles worked into the ninth inning, allowing two runs on eight hits, striking out eight and walking none., as the Sooners took game one of the three-game series with archrival Texas 4-2.
For Texas, it was the 11th loss in the last 13 games, and it was the third straight win for OU over its Red River rivals dating back to last season.
The Big 12 saves leader, Jason Ruffcorn, came on in relief of Wiles in the final frame and used three pitches to get the final three outs and pick up his 11th save.