My thinking on "sportsmanship" and running up the score has evolved over the years. I used to be an absolute purist on the subject, which you could cynically say was a result of me rooting for Jim Tressel teams that were largely incapable of running up the score on anybody anyway, so obviously I'd be against the practice.
But in my old (late 30's) age I've come to realize that literally the only consideration that I actually care about when it comes to late-game blowouts is the possibility of a star player getting potentially injured while doing a victory lap on the face of an opponent.