Villanova comes to Columbus as the higher-ranked team in the AP Poll, but the Wildcats won't be the favorite on Wednesday night as No. 16 Ohio State opens as a three-point favorite over No. 10 Villanova, according to betonline.ag.
The total for the game is set at 131.5 points, projecting about a 67-64 win for Ohio State.
The Buckeyes have started the season 2-0 with wins against Cincinnati and UMass Lowell, but the matchup with Wildcats figures to be the toughest test yet.
Ohio State will also be without a starter for Wednesday night's contest as Andre Wesson has been ruled out with an eye socket injury.