"Silver Bullets" is one of the more kickass monikers in college football.
In my mind, this is because a silver bullet is a thing designed to take out the worst monsters that lurk in the collective imaginations of our brains. If you have an irrational fear of the eldritch unknown, if you're afraid of what horrible monster might be at the end of the alleyway, a silver bullet is your best bet as a mere mortal to get out alive. It is a near-mythical weapon to help the hapless.
During the height of Tresselball, when Ohio State's offense often only existed in theory, the Buckeye defense was that weapon.