More and more lines are coming in for major college football games, and there's a general trend among just about everybody. The sharps like Ohio State this season, and quite a bit. ESPN has a series of lines from the Golden Nugget for big games this season, including multiple Ohio State games, and the Buckeyes are double digit favorites in all of them.
The Golden Nugget lines include:
Ohio State (-16) at Virginia Tech
Penn State at Ohio State (-19)
Michigan State at Ohio State (-14)
Ohio State (-16) at Michigan
The -16 is a little closer of a line for Virginia Tech than others that have recently been posted (-18, or even higher), but it's still a pretty big margin for a season opening road game against a tough team in an even tougher environment.