Notre Dame owns the edge in the recent rivalry with USC, winning five of the last eight meetings outright, including a blowout last season in South Bend, and going 6-3 against the spread over the last nine encounters. In the 90th edition of one of the great rivalries in college football the Irish tangle with the Trojans on Saturday night at the Coliseum in Los Angeles.
College football point spread: The Fighting Irish opened as eight-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
College football betting pick, via OddsShark computer: 41.