Notre Dame is 6-0 straight up and 5-1 against the spread in its last six games at home, while Nevada is 9-3 ATS in its last 12 games on the road. Trends collide when the Irish host the Wolf Pack on Saturday afternoon in South Bend.
Point spread: Fighting Irish opened as 26-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 36.0-25.2 Fighting Irish (College football picks on every game)
Why the Nevada Wolf Pack can cover the spread
The Pack opened this season with a 30-27 overtime victory over Cal-Poly last Friday.