Barnsley will be without former Norwich striker Carlton Morris because he is cup tied.
Norwich City boss Daniel Farke has confirmed midfielder Kenny McLean has tested positive for Covid-19 and will have to self-isolate.
Defender Christoph Zimmerman, midfielder Todd Cantwell and striker Teemu Pukki are all out injured.
The winner of the tie will host either Chelsea or Luton Town in the next round.
Match stats
- Barnsley have won just one of their past 16 meetings with Norwich in all competitions (D4 L11), losing 1-0 at Carrow Road in the Championship earlier this month.