Pseudouridine, an isomer of uridine (U), is used as a tumor marker to guide the diagnosis, monitoring and efficacy assessment of malignancies such as lung, breast and liver cancers. Although normal mRNA present in vivo has uridine as one of the four nucleic acid compounds in the sequence, mRNA developed as a therapeutic agent or vaccine is made using a modified nucleic acid (pseudouridine) instead of uridine (and other derivatives). Pseudouridine was originally present in the body as a component, such as tRNA (transfer RNA), which is a type of RNA.
Pseudouridine is also a major raw material for mRNA vaccines, and we expect that pseudouridine has a bright future with the expansion of production by international vaccine companies.