Three of the four teams in action on Saturday have a playoff clinching scenario in play.
The Kansas City Chiefs can move a step closer to the No. 1 seed in the AFC, the Pittsburgh Steelers will win the AFC North with a victory and the Baltimore Ravens are in the playoffs with a win.
The fourth Week 16 Saturday participant, the Houston Texans, are already locked into the postseason as the AFC South champion.
Only one division crown can be clinched in the NFC in Week 16.
The Philadelphia Eagles can lock up the NFC East crown if they are able to beat the Washington Commanders for the second time this season.