I think we've been here before. Last season, at the end of a Week 2 game in Tampa Bay, Christian McCaffrey suffered a high-ankle sprain that cost him the next six weeks and turned journeyman Mike Davis into a consistent RB2. This year, McCaffrey made it four days longer but pulled up with a hamstring injury on Thursday night in Week 3. And with Davis as a handcuff precedent and with an even clearer backup situation in Carolina this season, there isn't any doubt who the top waiver wire option is for Week 4.
Roster percentages are for ESPN/Yahoo.