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Twenty-two things to know about Week 4 injury report

Sammy Watkins will miss his second straight game this weekend. Could he be out indefinitely?

The team announced their star receiver will not play against the New England Patriots on Sunday and coach Rex Ryan told reporters there's "major concern" with his foot injury going forward. The Bills wideout has been dealing with foot pain stemming from offseason surgery and has just six catches for 63 yards this season.

The Bills also announced receiver Greg Salas (groin) and offensive linemen Cyrus Kouandjio (ankle) and Patrick Lewis (knee) are out for Sunday's tilt with the Patriots.