49ers defensive end Nick Bosa will miss the preseason with a "significant ankle sprain," general manager John Lynch told KNBR on Thursday.
San Francisco selected Bosa with the No. 2 overall pick in April's draft. The Ohio State product exited practice on Wednesday afternoon after a teammate fell on his leg.
“We won’t see him in the preseason and we’ll go from there,” Lynch said on Thursday. “We’ll get him right and he’ll be a great player for a long time in this league…We don’t feel he is injury prone… Yesterday he had a big human being fall on his leg while he was engaged with someone else.