The New Orleans Saints stumbled through last season, finishing with a losing record and missing the playoffs, but the team actually won their last four road games outright, going 3-1 against the spread. However, the Saints begin this season in a tough spot when they take on the Cardinals in Glendale, Arizona, Sunday afternoon.
Point spread: Cardinals opened as three-point favorites; the total was 48 early in the week, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
NFL pick, via Odds Shark computer: 27.