Matchups may not be the first thing that comes to mind when thinking of the top-tier talents in fantasy football.
These are the no-brainer, set-them-and-forget-them players leading your roster, so there really isn't much thought given to the stars during the course of the week, beyond hoping for good fortune on the health front.
Having said that, every NFL defense is different, and those differences matter even for the elites going against them.
It's not that a tough matchup will force you to pull a top draft pick out of your lineup, but a great matchup might set the table for a fantasy eruption.