But in the Matt Nagy-Mitch Trubisky-Vic Fangio era, the Bears are undefeated against Brady and Bill Belichick.
Here are 5 things that likely need to happen for it to stay that way when the 4-2 Patriots visit the lakefront Sunday.
1) Mitch staying hot
Bears QBs Jim Miller, Chris Chandler, Rex Grossman and Jay Cutler were a combined 61-of-118 for 667 yards, 4 touchdowns and seven interceptions (55.3 passer rating) in four meetings with New England’s Brady-Belichick duo. In five games this season, Trubisky has a 105.6 rating with 11 TDs and 4 INTs (also two lost fumbles).