The 49ers placed running back Jerick McKinnon on the injured reserve with a knee injury.
McKinnon will be out the entire 2019 season, and 49ers general manager John Lynch said the veteran will require knee surgery.
"He needed to undergo another procedure where being available in eight weeks wasn't an option," Lynch said, per Bay Area News Group's Cam Inman. "We're hopeful for Jerick that this one will be successful. There were some mechanical issues that did not allow him to play."
NFL Network's Ian Rapoport reported on Friday that McKinnon "had a bit of a flare up" recently.