San Francisco 49ers tight end George Kittle is going on injured reserve because of a calf issue, according to NBC Sports Bay Area's Matt Maiocco.
Kittle will have to miss at least three games before he's eligible to return, and Maiocco reported the Niners are hopeful he'll be available Nov. 7 when they play the Arizona Cardinals.
Kittle, a two-time Pro Bowler who earned All-Pro honors in 2019, has caught 19 passes for 227 yards in four games this season.
Last season, Kittle suffered a knee sprain in Week 1 against the Arizona Cardinals and missed two games.