The placed wide receiver Brandon Aiyuk, left tackle Trent Williams and tight end Daniel Helm on the reserve/COVID-19 list on Friday, per Tom Pelissero of NFL Network.
Per Matt Barrows of The Athletic, seven 49ers are now on the list. The other four players are defensive linemen Arik Armstead and Javon Kinlaw, center Hroniss Grasu and linebacker Joe Walker.
Aiyuk and Williams have been on the list twice. Placement there either means that a player has tested positive for COVID-19 or has come in close contact with someone who has.
This article will be updated to provide more information on this story as it becomes available.