Arsenal, Chelsea and Manchester City are among those who are currently suffering with several key players out.
Mikel Arteta's side will be sweating over the injury to Declan Rice. The midfielder, who the Gunners signed from West Ham in the summer, was forced off during their draw with Tottenham.
Their fellow London rivals, Chelsea, are another team who have had their problems with injuries this season. The side have endured a torrid start the new campaign and currently sit 14th in the table following their recent defeat to Aston Villa.