Southampton striker Danny Ings could be out for up to six weeks as he requires minor surgery on a knee injury.
Saints also have concerns over the fitness of Jan Bednarek, Ryan Bertrand and Ibrahima Diallo, who all suffered injuries during the win at Aston Villa.
Newcastle trio Matty Longstaff, Paul Dummett and Ciaran Clark have all returned to training and could play their first league games of the season.
Jonjo Shelvey, Martin Dubravka and Matt Ritchie remain sidelined.
MATCH FACTS
Head-to-head
- Southampton have lost four of the past five meetings.