Although there will also be much focus on the FA Cup this weekend, there are some hugely important games in the Premier League.
The race to finish in the top four continues, with Tottenham kicking off the weekend's action at home to Brighton. Arsenal can't afford to slip up away to Southampton, while Manchester United need a morale-boosting win against Norwich.
On Sunday Burnley begin life after Sean Dyche with a trip to face West Ham, who are still hopeful of getting into the top four.
Sportsmail's Lewis Steele provides his guide to this weekend's action.