Oxford United could hand a debut to striker Toni Martinez after his loan move from West Ham, but forward Chris Maguire (thigh) faces a fitness test.
Goalkeeper Manny Agboola, 18, will be on the bench after being recalled from a loan spell at North Leigh.
Newcastle boss Rafael Benitez is likely to make changes again.
Striker Aleksandar Mitrovic (knee) and midfielder Jack Colback (illness) could return.
Oxford United manager Michael Appleton told BBC Radio Oxford:
"If we beat Newcastle, it would probably be as big a win for me as I've ever had as a manager.