Sean Longstaff could return to Newcastle's starting line-up after only featuring as a substitute against Aston Villa following a bout of tonsillitis.
Fit-again Miguel Almiron is also in contention to start but Allan Saint-Maximin and Emil Krafth remain out.
Tottenham will assess Clement Lenglet, who was forced off against Bournemouth.
If he is unavailable, the centre-back is likely to be replaced by Davinson Sanchez, who was booed by Spurs fans last weekend, or Japhet Tanganga.
Lucas Moura completes a three-game ban, while Emerson Royal, Ryan Sessegnon, Rodrigo Bentancur and Yves Bissouma are still injured.
Ben Davies is back in training after recovering from a hamstring problem but this game will probably come too soon for him.