Newcastle boss Eddie Howe faces a selection headache with strikers Callum Wilson and Alexander Isak both on form.
Allan Saint-Maximin is not yet ready to return from a hamstring issue, while Emil Krafth remains sidelined.
Southampton may need to assess captain James Ward-Prowse, who felt unwell earlier in the week and was withdrawn at half-time against Bournemouth.
Full-back Romain Perraud will also be monitored after being forced off in the first half of Thursday's defeat.
Manager Ruben Selles says Armel Bella-Kotchap was left out in midweek because he "was not ready to perform" but has confirmed the German defender will be fit for Sunday.