Newcastle's Allan Saint-Maximin should be fit after a foot problem while Paul Dummett is back following a calf issue.
Boss Steve Bruce says it is "touch and go" whether Isaac Hayden, who has a knee injury, will be fit to play.
Southampton midfielder Stuart Armstrong is out with a calf problem while long-term absentee Will Smallbone also remains sidelined by a knee injury.
Manager Ralph Hasenhuttl is likely to rotate his line-up after Saints' record 8-0 away win at Newport in midweek.
LAWRO'S PREDICTION
Newcastle have lost both of their games so far and it seems as though the wagons are circling around Steve Bruce.