Newcastle head coach Steve Bruce says "the time is right" to hand leading goalscorer Callum Wilson his first start since 6 February.
However, on-loan midfielder Joe Willock is ineligible to face his parent club.
Arsenal head coach Mikel Arteta will assess the fitness of his squad in the wake of Thursday's Europa League semi-final first leg against Villarreal, and with next week's return game in mind.
Pierre-Emerick Aubameyang came on as a substitute in midweek but Arteta intimated the striker is not yet fit enough to start as he continues his recovery from malaria.
LAWRO'S PREDICTION
Arsenal's priority has to be the Europa League now because it is the only way they are getting into Europe next season.