Eddie Howe will be in the dugout for the first time as Newcastle manager as they visit Arsenal on Saturday.
The new Magpies boss, 43, returned a negative test for coronavirus on Friday, a week after being forced to miss his first game in charge.
The ex-Bournemouth boss missed last Saturday's draw with Brentford after testing positive the previous day.
There are no new cases at Newcastle, who are bottom of the Premier League with six points from 12 games.
Assistant manager Jason Tindall said: "From my own personal experiences when I had Covid a couple of months ago, I had no symptoms to start with and it was only after about eight or nine days where it hit me really hard and I began to struggle.