Leeds top scorer Patrick Bamford is fit despite his early substitution against West Ham, while influential midfielder Pablo Hernandez is back in training.
Central defenders Robin Koch and Diego Llorente are among the absentees.
Newcastle are assessing fatigue levels within their squad after their recent Covid-19 outbreak.
Defender Federico Fernandez has recovered from the virus, while Ryan Fraser is also available following a hamstring strain.
LAWRO'S PREDICTION
Leeds are naive at the back and that is going to cost them at times this season.
Yes, they created some good opportunities against West Ham on Friday night but the flipside of that was that the Hammers were able to play right through them.