Brentford could give a debut to midfielder Christian Eriksen, who hasn't played since suffering a cardiac arrest during Euro 2020 last summer.
Forward Ivan Toney could return after missing three games with a calf injury.
Newcastle will assess winger Allan Saint-Maximin's calf problem ahead of the trip to London.
Ryan Fraser has recovered from a muscle injury, while Javier Manquillo is back in training after damaging ankle ligaments earlier this month.
LAWRO'S PREDICTION
Brentford have taken only one point from their past seven games, and a resurgent Newcastle will go above them with a win on Saturday.