Emile Smith Rowe could be involved for Arsenal after four months out with a groin injury.
Newcastle left-back Matt Targett has been ruled out for the foreseeable future because of a heel injury.
He joins Alexander Isak, Jonjo Shelvey, Emil Krafth and Paul Dummett on the sidelines, while goalkeeper Martin Dubravka has been recalled from his loan spell with Manchester United.
CHRIS SUTTON'S PREDICTION
I was wrong about both of these teams last time out - Newcastle were unlucky not to beat Leeds, but I was miles out when I said Arsenal would lose to Brighton, although the Gunners had to weather a storm at the end of the game.