Arsenal hope left-back Kieran Tierney will be available after a scan revealed his calf injury is not serious.
Newcastle captain Jamaal Lascelles could make his first league appearance for two months, having played 45 minutes of the FA Cup defeat at Arsenal on his return from coronavirus.
Allan Saint-Maximin is also close to making his comeback after contracting the virus back in November.
Jamal Lewis and Federico Fernandez will be assessed, while Ryan Fraser is suspended as a result of his red card against Sheffield United.
LAWRO'S PREDICTION
These two teams met in the FA Cup last week, when Arsenal needed extra time to get through.