This is a rather special round of FA Cup action, with it all taking place in midweek for the very first time. The action commences on Monday night as Portsmouth host Arsenal, and clubs are again starting to dream of securing their spot at Wembley.
There are some enthralling ties ahead of us, with Chelsea hosting Premier League champions-elect Liverpool while Wayne Rooney prepares for a special reunion with former side Manchester United at Pride Park.
Here, Sportsmail runs you through the 10 things to keep a close eye on when the FA Cup fifth-round action gets underway on Monday night.