A bunch of fielding mishaps come back to haunt the Yankees.
In the first inning, fielding mistakes by Carlos Beltran and Stephen Drew cost the Yankees a run. In the fifth, a pair of mistakes by Chase Headley and Drew cost the Yankees two runs. When you only score three yourself, you aren't going to win a game when you gift the other team that many runs. That's what happened, and it allowed the Orioles to take the series with a 5-3 win over the Yankees.
The Orioles got on the board early.