In the Round of 16, the Red Bulls had a strong balance on both sides of the field as they advanced 5-0 on aggregate. Austrian winger Daniel Royer scored a goal in each leg, with Sean Davis and Andreas Ivan adding a goal apiece in the home leg. Captain Luis Robles and the backline kept two successive clean sheets allowing only one shot on target through 180 minutes against Pantoja.
Santos enters the quarterfinals following an 11-2 aggregate win over Club Deportivo Marathón of Honduras. The Liga MX side had seven different players score in the series, with three players scoring at least three.