Born in Caracas, Venezuela, Luis Guillorme immigrated to the United States along with his family in 2007, settling down in Davie, Florida. He enrolled in Coral Springs Charter High School in Coral Springs, Florida and quickly became known to scouts in the area, who began referring to him as a human highlight reel. The Mets selected the shortstop in the 10th round of the 2013 MLB Draft, and he forwent his commitment to State College of Florida to sign with the Mets for a $200,000 signing bonus, slightly over slot value for a 10th round pick.