"To me, it looks like he's getting run down," said Collins, who told reporters he is considering whether to push deGrom's next start back in to get him additional rest.
According to Collins, he will meet in New York with Sandy Alderson before making a final decision.
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In his last two starts, including Wednesday against the Cardinals, deGrom has given up 25 hits and 13 runs in just 9.2 innings, while striking out eight batters. He had been 4-1 with a 1.29 ERA in the nine starts prior to last week.
Collins said Wednesday the Mets would talk Thursday about what to do with deGrom and how to handle the rotation, now that Steven Matz and Jon Niese are on the disabled list.