A three-year varsity letterman at Zionsville High School in Zionsville, Indiana, Nate Dohm established himself as one of the best pitchers in Indiana and one of the best prospects in the state, period. In his senior season, he posted a miniscule 0.98 ERA in 42.0 innings with 19 hits allowed, 14 walks, and 90 strikeouts. He went undrafted in the 2021 MLB Draft and attended Ball State University that fall, a school he decided on because it was a fairly local and he and his family considered it a good developer of pitching talent.
He appeared in 15 games for the Cardinals in his freshman year, starting 3 games, and posted a 5.