A native of Diamond Bar, California, D’Andre Smith attended San Dimas High School. Between 2017 and 2020, the four years he attended, the San Dimas Saints went 77-17 overall and 30-2 in Valle Vista League games, claiming league championships in 2017, 2018, and 2019, and Smith was a major reason why. A versatile player able to man positions all over the field but mainly played shortstop, he hit a cumulative .362 with 29 doubles, 4 triples, and 2 home runs over the course of his career there. He went undrafted in the COVID-shortened 2020 MLB Draft and honored his commitment to the UNC.