All odds via ESPN BET
- Jacksonville Jaguars @ Chicago Bears: +1
- Cleveland Browns @ Philadelphia Eagles: -9.5
- Arizona Cardinals @ Green Bay Packers: -5
- Washington Commanders @ Baltimore Ravens: -6.5
- Houston Texans @ New England Patriots: +6.5
- Indianapolis Colts @ Tennessee Titans: -2.5
- Tampa Bay Buccaneers @ New Orleans Saints: +3.5
- Pittsburgh Steelers @ Las Vegas Raiders: +3
- Los Angeles Chargers @ Denver Broncos: +3
- Atlanta Falcons @ Carolina Panthers: +6
- Detroit Lions @ Dallas Cowboys: +3.