All odds via FanDuel Sportsbook
- Jacksonville Jaguars @ Buffalo Bills: -5.5
- Houston Texans @ Atlanta Falcons: -2.5
- Carolina Panthers @ Detroit Lions: -9.5
- Tennessee Titans @ Indianapolis Colts: +2.5
- New York Giants @ Miami Dolphins: -12.5
- Baltimore Ravens @ Pittsburgh Steelers: +4.5
- New Orleans Saints @ New England Patriots: +1.5
- Cincinnati Bengals @ Arizona Cardinals: +3
- Philadelphia Eagles @ Los Angeles Rams: +4.5
- Kansas City Chiefs @ Minnesota Vikings: +3.5
- New York Jets @ Denver Broncos: -2.