All odds via ESPN BET
- Philadelphia Eagles @ New Orleans Saints: -2.5
- New York Giants @ Cleveland Browns: -6.5
- Green Bay Packers @ Tennessee Titans: -2.5
- Chicago Bears @ Indianapolis Colts: -1.5
- Houston Texans @ Minnesota Vikings: +2
- Denver Broncos @ Tampa Bay Buccaneers: -6.5
- Los Angeles Chargers @ Pittsburgh Steelers: -1.5
- Miami Dolphins @ Seattle Seahawks: -4
- Carolina Panthers @ Las Vegas Raiders: -5
- Baltimore Ravens @ Dallas Cowboys: +1
- San Francisco 49ers @ Los Angeles Rams: +7
- Detroit Lions @ Arizona Cardinals: +3
- Kansas City Chiefs @ Atlanta Falcons: +3.