All odds via ESPN BET
- Buffalo Bills @ Miami Dolphins: -2.5
- Indianapolis Colts @ Green Bay Packers: +2.5
- New York Giants @ Washington Commanders: -1.5
- Los Angeles Chargers @ Carolina Panthers: +6
- New York Jets @ Tennessee Titans: +4
- San Francisco 49ers @ Minnesota Vikings: +5.5
- New Orleans Saints @ Dallas Cowboys: -6
- Seattle Seahawks @ New England Patriots: +3.5
- Cleveland Browns @ Jacksonville Jaguars: -3
- Las Vegas Raiders @ Baltimore Ravens: -9
- Tampa Bay Buccaneers @ Detroit Lions: -7.