All odds via ESPN BET Sportsbook
- Pittsburgh Steelers @ Baltimore Ravens: +3
- Houston Texans @ Indianapolis Colts: +1.5
- New York Jets @ New England Patriots: -2
- Cleveland Browns @ Cincinnati Bengals: -7
- Jacksonville Jaguars @ Tennessee Titans: +3.5
- Atlanta Falcons @ New Orleans Saints: -3
- Tampa Bay Buccaneers @ Carolina Panthers: +4.5
- Minnesota Vikings @ Detroit Lions: -3.5
- Denver Broncos @ Las Vegas Raiders: -3
- Dallas Cowboys @ Washington Commanders: +13
- Chicago Bears @ Green Bay Packers: -3
- Seattle Seahawks @ Arizona Cardinals: +3
- Los Angeles Rams @ San Francisco 49ers: -4
- Kansas City Chiefs @ Los Angeles Chargers: -3.