All odds via ESPN BET Sportsbook
- Detroit Lions @ Dallas Cowboys: -5.5
- New England Patriots @ Buffalo Bills: -14
- Los Angeles Rams @ New York Giants: +6
- Tennessee Titans @ Houston Texans: -4.5
- New Orleans Saints @ Tampa Bay Buccaneers: -2.5
- Arizona Cardinals @ Philadelphia Eagles: -12
- Atlanta Falcons @ Chicago Bears: -3
- Miami Dolphins @ Baltimore Ravens: -3
- San Francisco 49ers @ Washington Commanders: +13.5
- Las Vegas Raiders @ Indianapolis Colts: -4
- Carolina Panthers @ Jacksonville Jaguars: -4
- Pittsburgh Steelers @ Seattle Seahawks: -4
- Los Angeles Chargers @ Denver Broncos: -3.