All odds via ESPN BET Sportsbook
- Green Bay Packers @ Carolina Panthers: +4
- Seattle Seahawks @ Tennessee Titans: +3
- Cleveland Browns @ Houston Texans: +3
- Indianapolis Colts @ Atlanta Falcons: -3
- Washington Commanders @ New York Jets: -3
- Detroit Lions @ Minnesota Vikings: +3
- Jacksonville Jaguars @ Tampa Bay Buccaneers: +1
- Dallas Cowboys @ Miami Dolphins: -2.5
- Arizona Cardinals @ Chicago Bears: -4
- New England Patriots @ Denver Broncos: -7
- Las Vegas Raiders @ Kansas City Chiefs: -10.