All odds via ESPN BET Sportsbook
- Minnesota Vikings @ Cincinnati Bengals: -3
- Pittsburgh Steelers @ Indianapolis Colts: -1
- Denver Broncos @ Detroit Lions: -5
- Chicago Bears @ Cleveland Browns: -3
- New York Jets @ Miami Dolphins: -8.5
- New York Giants @ New Orleans Saints: -5.5
- Kansas City Chiefs @ New England Patriots: +8
- Tampa Bay Buccaneers @ Green Bay Packers: -3.5
- Houston Texans @ Tennessee Titans: -3
- Atlanta Falcons @ Carolina Panthers: +3
- Washington Commanders @ Los Angeles Rams: -6.