All odds via ESPN BET Sportsbook
- Los Angeles Rams @ Baltimore Ravens: -7.5
- Carolina Panthers @ New Orleans Saints: -6
- Indianapolis Colts @ Cincinnati Bengals: -2.5
- Jacksonville Jaguars @ Cleveland Browns: -2.5
- Tampa Bay Buccaneers @ Atlanta Falcons: -2.5
- Detroit Lions @ Chicago Bears: +3.5
- Houston Texans @ New York Jets: +3.5
- Seattle Seahawks @ San Francisco 49ers: -13.5
- Minnesota Vikings @ Las Vegas Raiders: +3
- Denver Broncos @ Los Angeles Chargers: -2.5
- Buffalo Bills @ Kansas City Chiefs: -1
- Philadelphia Eagles @ Dallas Cowboys: -3.